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NNMT inhibition works by blocking an enzyme, not by overstimulating a receptor, so the usual receptors desensitize and stop responding pattern that drives cycling for a lot of peptides doesnt obviously apply here

A 150lb individual and a 250lb individual should not use identical doses and expect equivalent results

So instead of supporting metabolism, NNMT is effectively siphoning off key resources your cells need to function

Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

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