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Simultaneously, the mechanical properties of the ECM change significantly: the shear stiffness of the human nucleus pulposus increases from 12.5 kPa in Pfirrmann grade 116.5 kPa in grade V (Walter et al., 2017), collagen fibers thicken and become disorganized (Wuertz et al., 2007) (Table 1)

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High doses of biotin can lead to false results, making it difficult for healthcare providers to assess thyroid function accurately

High mobility group box 1 (HMGB1): HMGB1 is a nuclear protein that plays essential roles within the cell, such as organizing genetic material and facilitating DNA repair

The possible role of this extra domain in PVC remains unknown [30]