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Type 2 cells can be differentiated based on the expression of different proteins into type 2a and 2b, with type 2b cells beginning to show a neuronal lineage

Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs