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Trontinemab, an anti-amyloid monoclonal antibody fused to a transferrin receptor-binding shuttle module designed to enhance receptor-mediated transcytosis, is currently being evaluated in Phase I/II clinical studies, with early data indicating substantially increased brain exposure compared with conventional antibodies ( It is worth noting that an important limitation in the translation of preclinical findings to humans is the heavy reliance on transgenic mouse models, particularly APP/PS1 and 5xFAD