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Biochem J 123:211218 Benjamin AM, Quastel JH (1972) Locations of amino acids in brain slices from the rat

Pereira et al ., 2022

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In this regard, we need to closely combine different disciplines, research models and characterization tools to deeply reveal the molecular mechanisms of MSNs-based nanomedicines and elucidate the action behavior between materials and biological interfaces

AML cells are completely dependent on exogenous GLN, and knockdown of high-affinity ASCT2 leads to apoptosis in AML cell lines and inhibits tumor progression in AML xenografts and primary AML mouse models [47] Indeed, ASCT2 plays pleiotropic roles in cellular metabolism and serves as a promising molecular target for the treatment of leukemia [27]