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Higher doses of thalidomide over a short period of time were associated with lower risk for CIPN compared to regimens that involved a lower dose of thalidomide over a longer period (Priolo et al., 2008

It has fast-acting antidepressant effects, and animal studies show that the effects on behavior last well beyond the half-life

VALOR was a phase III, randomized, double-blind, placebo-controlled study that has evaluated the efficacy, safety, tolerability, and pharmacodynamic effects of tofersen on ALS with a confirmed SOD1 mutation (NCT02623699)

Diaz-Angulo, S., Lopez-Hoyos, M., Munoz-Cacho, P., Lopez-Escobar, M

Even brief exposure to humid air can trigger partial breakdown as the peptide begins to rehydrate unevenly