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Biological evaluations included in vitro studies using neuroblastoma cells (SH-SY5Y) and human brain microvascular endothelial cells (HBMECs) to assess the ability of the nanoparticles to cross the BBB and effectively target neuronal cells

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However, someone with a more severe, long-standing deficiency might need to wait a little longer, possibly requiring multiple injections over several weeks or months to fully replenish their B12 stores and reverse symptoms