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(C) The proportion of patients with response to immunotherapy in low SLC25A39 expression group and high SLC25A39 expression groups in the GSE35640 immunotherapy cohort (65 metastatic melanoma patients received MAGE3 inhibitor treatment), and in the GSE176307 immunotherapy cohort (89 urothelial cancer patients received PD1/PDL1 inhibitor treatment)

However, most current studies rely solely on the EAE mouse model and the LPC-induced localized myelin loss model, which do not fully recapitulate the complex pathological features of MS, particularly its heterogeneity, disease progression, and clinical symptoms

doi: 10.7150/thno.19403

However, clinical trials suggest that the side effects of TB500 are generally considered mild and rare, particularly when used at appropriate dosages

Chronic stress and inflammatory stimuli promote microglial activation, leading to sustained release of pro-inflammatory cytokines, reactive oxygen and nitrogen species, and excitotoxic mediators that disrupt synaptic function and neuronal integrity (30)