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Studies that met the inclusion criteria were systematically evaluated by two reviewers independently

In fact, cobalamin deficiency is a common cause of metabolic encephalopathy, one of a number of forms of encephalopathy associated with a primary disease (such as FIP) that causes interference with normal brain function and blood-brain barrier mechanisms

doi: 10.1093/jac/dky282 144 LiuXSunXZhangYJiangWLaiMWigginsKLet al

doi: 10.1038/s41420-022-01212-0 101 WangWGreenMChoiJEGijnMKennedyPDJohnsonJKet al

Factors including administration period, amino acid intake, dosage, and carnitine palmitoyl transferase (CPT) activity are considered associated with these discrepancies 3, 4 , suggesting that the possible use of the compound in this context is yet to be fully explored