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In contrast, evidence for chronic neuroinflammation in subcortical structures such as the CN remains more limited, although reversible inflammatory gene expression changes have been reported in the IC and MGB in salicylate models (Xia et al., 2020

Results continue to vary based on individual factors

And, like Bufka, she cautions that when assessing creatines effect on anxiety, the limited research leaves us with limited answers. Creatine and Mood A review suggests that creatine might have an antidepressant and mood-improving effect

Consequently, pro-inflammatory mediators such as TNF- can be secreted by macrophages (60)

Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases