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Prime-boost vaccine strategy against viral infections: Mechanisms and benefits

J Hepatol 2015;63:1190-1197

[1] This cycle ensures that cells maintain the optimal GSH:GSSG ratio of 10:1 to 100:1, a critical indicator of cellular health

In contrast, MYCN-amplified cell lines exhibited radioresistance under the same conditions, suggesting that targeting Gln metabolism can be beneficial for the treatment of c-MYC-driven but not MYCN-amplified neuroblastoma [134]