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dataset showed that GPX4 demonstrated the highest variability (standard deviation of log2 fold changes = 0.39), followed by EIF3B (0.26) and ST3GAL1 (0.24)

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Applied to the two compounds here, the framework is clarifying

Thioredoxin reductase is a key factor in the oxidative stress response of lactobacillus plantarum WCFS1

A key issue concerns to what extent any of the signaling mechanisms discussed in this review are impacted by physiologically relevant changes in glutathione status or whether they merely require a threshold concen- tration or reduction state of the substrate