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However, the dysregulation in the pathways that regulate B12 metabolism may influence the serum level of vitamin B12, and the dysregulation of the metabolism of this vitamin may be the driver of higher levels of vitamin B12 in the circulation

(b) the paracellular route used by ions, water and larger hydrophilic compounds from ~400600 Da up to 1020 kDa and that cannot cross transcellularly [regulated by the tight junction (TJ) proteins]

Residual sperm can persist in ejaculate for 8-16 weeks after the procedure, making follow-up semen analysis at 8-12 weeks mandatory to confirm sterility