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The antimetabolite, irinotecan, similarly induces diarrhea and causes weight loss in rodents

J Pharmacol Exp Ther (1991) 257:66875

demonstrated that LDLR is overexpressed at all stages of pancreatic cancer progression and is strongly associated with an increased risk of cancer recurrence

Moving too quickly can lead to frustration, fatigue, and a rebound effect: it's better to gradually establish realistic habits that are easy to maintain long-term