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Medications : first line option for men with mild to moderate symptoms Alpha blockers Tamsulosin (Flomaxtra), Prazosin (Pressin), Alfuzosin (Xatral) relax the muscles within the prostate and improve urinary flow start working quite quickly (within 48 hours) 5 alpha reductase inhibitors Finasteride (Proscar), Dutasteride (Avodart) lower the testosterone level within the prostate, progressively causing shrinkage of the prostate take at least 3 months to begin improving symptoms Combination of the above 2 Tamsulosin and Dutasteride (Duodart) Offer both rapid symptom relief and progressive shrinkage of the prostate Most effective medication at improving urinary symptoms caused by BPH 3

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Structural basis for the interaction of TAK1 kinase with its activating protein TAB1

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