napqi glutathione Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants SUPER EASY MEMORY Too much
SUPER EASY MEMORY Too much Tylenol More NAPQI Less glutathione Liver dies NAC More glutathione Liver saved Paracetamol toxicity Biochemical Basis Lecture Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins.
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