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Two studies investigated the ACC/mPFC and one of these studies found increased glutamine/glutamate ratio [40] while the other found no significant abnormalities in glutamate levels in schizophrenia [41]

Future research can focus on using specific gene knockout/knock-in animal models and combining single-cell sequencing technology to clarify the spatiotemporal expression patterns and functional differences of p53 in different cell types (such as chondrocytes, synoviocytes, and osteoclasts) and different stages of OA

While vitamin B12 deficiency is common and well-understood, elevated B12 levels can occasionally occur

For example, an older patient with arthritic hips that is going to be positioned for an abdominal exploratory requires hip support in addition to systemic analgesia

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