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With purity levels above 99%, it supports reliable studies involving glucose regulation, insulin pathways, and appetite signaling

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Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

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Elegant review studies are already published elsewhere (Jiang and Cadenas, 2014