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Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs

10.1016/S1474-4422(08)70092-9 Lancet Neurol

SUMMARY We recently discovered that inhibition of the lipid peroxidase GPX4 can selectively kill cancer cells in a therapy-resistant state through induction of ferroptosis

In the human aortic wall, hepcidin activates the TLR4/NF-B pathway to initiate hepcidin autocrine-induced iron retention in murine macrophages [9], and enhances inflammation-mediated AS [29]

(33)] found that intermittent fasting in older mice (14 months old) can enhance the activity of the nicotinamide adenine dinucleotide (NAD+)/Sirt1 antioxidant system, which reduces ROS accumulation, prevents DNA damage and cell apoptosis, increases follicle numbers, and improves oocyte meiotic and embryo development capabilities, thereby significantly delaying reproductive aging