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According to this model, the protein is initially in an open inward-facing state where no nucleotide or cargo is bound with well-separated NBDs

doi: 10.4049/jimmunol.1701382 111 GuoWGongQZongXWuDLiYXiaoHet al

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Besides these increments in BCAAs and ArAAs, we also found reduced plasma levels of arginine and glutamine in children with obesity, in line with previous studies reporting disrupted nitrogen metabolism through the urea cycle and impaired production of nitric oxide [4]