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This simple technique stops the solution from foaming and prevents you from directly blasting the powder, which can make it clump up

cloudiness, particulates, or color change in a previously clear solution are cited as signs to discard and start a new vial

10.1016/j.bioorg.2024.107399 61 KwonO

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Unlike ivermectin, which does not penetrate the blood brain barrier well, some benzimidazoles such as mebendazole can penetrate this barrier, and therefore show promise for some cancers of the brain as well