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10.1161/CIRCRESAHA.119.314681 65

doi: 10.1017/S1461145710000805 [DOI] [PubMed] [Google Scholar] 12.Sequeira A, Martin MV, Rollins B, et al

-- March 10, 2014 The accordion-muzzled cavalier King Charles spaniel

Based on the working hypothesis of P-gp-dependent collateral sensitivity [14,15,16,17], we examined the ability of tamoxifen as a collateral sensitivity drug for two reasons: a) tamoxifen has been previously shown to activate P-gp ATPase at clinically achievable concentration (46 M) [20, 21], and b) tamoxifen is widely used in the treatment of estrogen receptor-positive breast cancer [22]