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Other important constituents also include several isoflavonoid derivatives such as shinpterocarpin, glabrone, glabridin, galbrene, lico-isoflavones A and B (Asl and Hosseinzadeh, Figure 9 Due to their antioxidative properties, several species of Glycyrrhiza were investigated for possible therapeutic effects as neuroprotectants against neurodegenerative disorders such as PD, AD, and dementia

Notably, the optimal in vivo neuroprotective dose was identified as 0.5 mg/kg, which produced substantial behavioral and histological improvements

Furthermore, for specific compounds, additional key mechanisms such as Fas-mediated signal transduction, loss of cellular redox homeostasis, ATP depletion, changes in ion channels, and activation of kinases and caspases, among others, have been highlighted

2.4.3 Chitosan Chitosan is a natural polysaccharide derived from the deacetylation of chitin, commonly found in the shells of crustaceans such as shrimp and crab

AOD 9604 lyophilized powder should be stored frozen at -20 degrees C until ready for reconstitution