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C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)

The NLRP3 and NLRP12 inflammasomes are activated by various stimuli and help express IL-1 and IL-18 in PC [34]

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If baseline GH elevation begins to decline after 23 weeks on the higher dose, return to 1mg + 1mg for a 7-day washout period to allow receptor re-sensitization