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The intestine facilitates material exchange with luminal contents through specialized pathwaysnotably the paracellular pathway, which typically permits the passage of molecules larger than 15 (approximately 3.5 kDa) (51)

Nevertheless, excessive PEGylation can introduce unintended consequences, including increased protein adsorption, which may alter the biodistribution and pharmacokinetics of the nanomaterials

Ono et al., 2007): the A8 retrorubral field, A9 substantia nigra pars compacta (SNc), and A10 ventral tegmental area (Toulouse and Sullivan, 2008)

These patients should have their fluid status assessed and be appropriately hydrated prior to administration of Reclast

Yin Y, Zheng Z, Jiang Z