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In fact, NRF2 activation as a clinical target is well established for the treatment of MS since the potent NRF2-activator dimethyl fumarate (DMF) was approved by FDA as first disease-modifying agent in 2013 (Fox et al., 2012

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16 In comparison to cyclosporine monotherapy in Table 1, the average duration of cyclosporine for steroid-dependent and steroid-resistant DRESS is 41.6 days, indicating a longer duration with a slower tapering process

The analysis revealed that both the comproportionation and triad models were better suited to represent the experimental data than the reduced model, but were inconclusive with respect to overall model selection, given that both AIC/BIC values were extremely similar (Fig

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