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Heavy amphetamine use of any kind, including prescription stimulants, can result in tolerance, physical dependence, and a withdrawal syndrome upon abrupt cessation

Deficiency of vitamin B12 can impair the remethylation of homocysteine in which homocysteine cannot be converted to the amino acid methionine thus accumulating cellular folate as 5-methyl THF

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Minerva etal Fewer adults had low or transitional vitamin B12 status