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Regarding vitisin A, it specifically aborts the cell cycle at G1 phase (Shin 2015)

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Each deacetylation cycle of SIRT1 consumes one NAD molecule, producing acetyl-ADP-ribose (1-O-acetyl-ADP-ribose or 2- and 3-O-acetyl-ADP-ribose) and nicotinamide as byproducts (Liu et al., 2022a

Although the oxidative phosphorylation pathway can produce energy in times of stress to aid in the survival of astrocytes and neurons, other pathways have also been found to be capable of sustaining astrocyte survival in the event of mitochondrial inhibition (San Martin et al., 2017)