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J Ethnopharmacol 301:115819

Assuming that the lower temperature (20 C) enhanced glutathione biosynthesis in batch fermentation and hindered cell growth in the fed-batch system, the culture temperature was increased to 30 Cthe optimal growth temperature for S

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However, this preservation of mitochondrial function creates a paradox: by maintaining the electron transport chain, CHAC1 inadvertently supplies the ROS that propagate iron-dependent lipid peroxidation ( via two convergent mechanisms: the direct depletion of glutathione and the indirect facilitation of mitochondrial ROS production, thereby coupling sustained metabolic activity to ferroptotic cell death under cysteine limitation