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Description

The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses

All authors contributed toward data analysis, drafting and revision of the manuscript, and have read and approved the final manuscript

D.Nasr-EsfahaniM

Mechanistic studies in mouse islets and INS-1E cells (191) further clarify that butyrate inhibits IL-1-induced expression of inflammatory genes (Nos2, Cxcl1, and Ptgs2) and NO production by suppressing NF-B activation