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Science 216 , 12331235 (1982)

Abstract Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis

302 Similar to the context-dependent dual roles of the SIRT1/PGC1 axis in tumorigenesis, the effects of SIRT3-mediated mitochondrial biogenesis on cancer are heterogeneous

However, BBB is compromised in the breast cancer brain metastasis, providing the presence of tumor-associated components including ctDNA or exosomes for entrance into the blood circulation or the CSF