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Description

Nature 2009

doi: 10.1111/bjh.17416

Glutaminolysis inhibits the conversion of GLN to circulating TCA metabolites by regulating various enzymes, and GLS is the first step in the process

However, based on the coordinated regulation of homocysteine metabolism by SAM, three main types of moderate to intermediate hyperhomocysteinemias can be proposed

Furthermore, we will discuss the emerging therapeutic applications of cuproptosis, focusing on copper chelators, copper ionophores, and copper-based nanomaterials that have shown promise in inducing cuproptosis and inhibiting tumor growth