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PMID: 7 BogaczM.Krauth-SiegelR

In 2021, Sun and colleagues reported a pioneering library of cereblon-based PROTACs targeting the degradation of glycogen synthase kinase 3 (GSK-3), a protein kinase considered a therapeutic target in neurodegenerative diseases

Ezh2 inhibitor GSK126 suppresses antitumor immunity by driving production of myeloid-derived suppressor cells

The currently known major regulatory mechanisms of ferroptosis involve intracellular lipid metabolism, iron metabolism, GSH-dependent pathway and CoQ 10 -dependent pathway as stated above

Moreover, significantly increased GPx activity in Parkinsons disease rat models was observed with the administration of selenium nanoparticles, along with improved antioxidant capacity and relieved oxidative stress