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Our Si-based agent also succeeded in alleviating the effect on the brain at the onset of UC

doi: 10.1007/s00404-012-2439-7 98 ClowerLFleshmanTGeldenhuysWJSantanamN

Supplementation with nicotinamide restores cellular NAD + pools and mitochondrial energetics, attenuates oxidative stress and inflammatory responses, enhances extracellular matrix and skin barrier, and inhibits the pigmentation processes [110]