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After being absorbed in the intestine, they modulate the CNS by crossing the blood-brain barrier, while supporting its integrity and prevent leakage, whose depletion can adversely lead to Alzheimers (Dinan & F, 2017

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Impaired Glucoronidation: The activity of the UGT enzymes that operate the process of glucuronidation can have genetic weaknesses that impair their function

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