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Zanotto-Filho A, Pragathi Masamsetti V, Loranc E, Tonapi SS, Gorthi A, Bernard X, Goncalves RM, Moreira JCF, Chen Y, Bishop AJR (2016) Alkylating agent-induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis

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Then, we treated mouse HL-1 cardiomyocytes with DOX and found that the ferroptosis markers were induced upon DOX treatment, such as ROS accumulation, lipid peroxidation, upregulation of PTGS2, as well as the release of myocardial enzyme lactate dehydrogenase (LDH), the well-known cardiomyopathy marker (Fig

Dec 24 2022;13(1)doi:10.3390/biom13010036