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Ann Neurol 55:729732

Prolonged BCL treatment in UC mice significantly reduces colonic FcRn levels, serum ANCA titers, neutrophil-activating peptide (NAP) expression, and inflammatory markers (including TNF-, IL-1, and CRP), while improving disease activity indices and histological scores, outperforming sulfasalazine (73)

Immunosuppressive cells also express arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO) which deplete levels of L-arginine and tryptophan, respectively, from the microenvironment and thus suppress the functions of effector immune cells [92] (Fig

Folate does not replace training, sleep, protein, or broader micronutrient sufficiency