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These cells exhibit greater plasticity and are predisposed to progressing through the metaplasia-dysplasia-cancer sequence (85)

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Bcl-2 family proteins play a key role in the regulation of mitochondrial membrane permeability and the release of apoptosis factors, while caspase protease, especially Caspase-3, acts as an apoptosis effector molecule to activate downstream apoptosis-related proteins and destroy cytoskeleton and housekeeping gene functions

the use of neuroimaging markers of cerebral small vessel disease improves classification with prognostic relevance