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Through its potent properties, it effectively enhances the activity of serum T-SOD, reduces malondialdehyde (MDA) content, alleviates oxidative stress, and exhibits significant anti-rheumatoid arthritis effects (31, 32)

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Biochim Biophys Acta 1724:108118

Collectively, these instances demonstrate the molecular diversity, clinical precedence, and potency amplification achievable through metal coordination

More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent