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Description

In multiple preclinical models, recombinant human CYGB (His-CYGB), delivered intravenously to mice with established cirrhosis (e.g., TAA, DDC), suppressed inflammation, reduced oxidative damage, and regressed fibrosis

Nature Metabolism 1(11):1074-1088

Complications and outcomes investigated included hepatic encephalopathy (HE), gastrointestinal bleeding (GIB), acute kidney injury (AKI), hepatorenal syndrome (HRS), bacterial infections, readmissions, and mortality at 28 and 90 days