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To accomplish this, error-prone PCR can be used to amplify the variable domain sequences (limited in some cases to CDR-encoding sequences) to produce millions of copies containing mutations, including but not limited to point, region, insertion, and deletion mutations

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Researchers have also identified mechanisms of ferroptosis that do not depend on GPX4, and a major component of this GPX4-independent pathway is ferroptosis suppressor protein 1 (FSP1) (24)

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Li Q, Li Q-Q, Jia J-N, Sun Q-Y, Zhou H-H, Jin W-L, Mao X-Y (2019) Baicalein exerts neuroprotective effects in FeCl3-induced posttraumatic epileptic seizures via suppressing ferroptosis