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The half maximal inhibitory concentration (IC50) of zebularine is approximately seven-fold higher than that of 5AC (120 M vs 17.4 M, respectively) in human bladder cancer T24 cells, with a degradation rate lower than 7% within 48 h ( Zebularine also inhibits cytidine deaminase, which confers resistance to nucleoside analogs (Zhang et al., 2021) and liver HepG2 (Zhou et al., 2011)

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Each dot represents one individual mouse in ( a , b , h k ) or a biological replicate ( e g )

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An interesting information to notice is that the phenolic compound quercetin is also present in a plant Houttuynia cordata Thunb., along with several other antioxidant phytochemicals (Kumar et al