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doi: 10.1039/9781849737876-00080 King, Glenn (2015)

(2022), embryonically-derived TREM2-dependent neuroprotective DAM and monocyte-derived TREM2-independent disease-inflammatory macrophages (DIMs) accumulate with aging and are conserved in humans

PMID: 2153863

**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A