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Transcription factors with the most connections to other genes included EPAS1 (also known as HIF-2), KLF13, TAL1, TBX3, GATA2, and BCL11A (Additional file 4)

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To reduce dimensionality and structure the data prior to clustering, a t-distributed Stochastic Neighbor Embedding (t-SNE) was applied to the TF-IDF matrix, producing two-dimensional embeddings

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