acetyl l carnitine chemotherapy induced neuropathy Frontiers Frontiers | Bortezomib-induced peripheral neuropathy:

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Oxidative stress is one of the most important mechanisms of increased cellular senescence and frailty, leading to a wide range of diseases that are common in the older population, including chronic lung disease, cardiovascular disease, chronic kidney disease, skeletal muscle dysfunction and cancer (188, 189)

In the diabetic kidney, increased delivery of glucose and reabsorption in the proximal tubule by the SGLT2 sodium-glucose co-transporter decreases sodium concentrations reaching the macula densa (61, 62)

Moreover, chronic alcohol consumption can lead to alterations in serotonin receptor expression and function

The study was initially designed as two-step study, enrolling additional patients ( n = 27) after observing at least one response (partial response or complete response) within the first group of 14 patients