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10.1016/j.ejphar.2024.176600 70 LiuT.CuiY.DongS.KongX.XuX.WangY.et al (2022b)

- B Biochem

The major limitations of these studies included were small sample size consisting of healthy Volunteers, extremely short study periods with an even shorter follow- up and Lack of measurement of Blood Levels of Glutathione.The investigators also did not estimate baseline or post- treatment renal or thyroid function of the Subjects, both of which were reported to be adversely affected by IV glutathione

doi: 10.1016/j.cell.2016.05.035 63 PengMYinNChhangawalaSXuKLeslieCSLiMOet al

Keap1/Nrf2/ARE, p53/SLC7A11 and GSH/GPX4 signaling pathways underlie the pathological mechanism of AD, positioning them as a potential direction for future research