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Additionally, a study by Liu et al (41) demonstrated that miR-196a promotes the development of non-small cell lung cancer by downregulating the expression of GPX3 and activating the JNK pathway, thereby enhancing the proliferation, differentiation, self-renewal ability and invasiveness of cancer stem cells (CSCs) (41)

The cell-killing effect of BSO&OXA@MOF-LR was markedly increased compared to that of BSO@MOF-LR or OXA@MOF-LR, indicating the synergistic effect of ferroptosis inducer and chemotherapeutic drug (Additional file 1: Fig

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3 Interactions of autophagy with the cGAS-STING pathway 3.1 cGAS The interplay between autophagy and cGAS occurs through (i) cGAS-Beclin-1 interaction that promotes autophagic degradation of cytosolic dsDNA, (ii) cGAS-LC3 interaction that promotes micronucleophagy, and (iii) degradation of cGAS through p62-mediated selective autophagy ( Figure 3 )

doi: 10.3389/fnins.2025.1559597 Received 29 January 2025 Accepted 05 March 2025 Published 19 March 2025 Volume 19 - 2025 Edited by Marcos Roberto De Oliveira, Federal University of Rio Grande do Sul, Brazil Reviewed by David Tattersall, GlaxoSmithKline, United States Serenella Medici, University of Sassari, Italy Updates Copyright 2025 Feng, Zhang, Liu, Wang, Dang, Han and Zhang