doi: 10.1055/s-2007-978704 41 DelaneyCLRussellJWChengH-LFeldmanEL
However, whereas NOS coupled with BH4 converts arginine into NO, NOS coupled with BH2 promotes the formation of superoxides and hydrogen peroxide, two highly toxic compounds, which are associated with several of the symptoms associated with BH4 deficiency
At least two independent experiments were conducted and samples were assessed in (at least) triplicate in each experiment
Antioxidant Activity Oxidative stress is involved in many pathological conditions, including cellular aging, cancer, and neurodegenerative diseases
Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramr EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM and Green KN (2021) Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimers Disease