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4.3 Mechanistic pathways linking vaginal microbiota, HPV persistence, and cervical carcinogenesis 4.3.1 Microbial metabolic pathways Research has demonstrated that alterations in the microbiome, instead of the influence of a solitary pathogen, are responsible for the majority of microbial carcinogenesis cases (Sobhani et al., 2019)

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Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages