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doi: 10.3389/fendo.2024.1489097 [DOI] [PMC free article] [PubMed] [Google Scholar] 9

Personalized Dosing Schedule Wegovy treatment usually begins with a gradual dose escalation over several weeks

Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer

Treatment response evaluation should focus on objective measures relevant to the specific indication being treated

The most durable results come when pharmacological support is embedded within a broader lifestyle framework: resistance training to provide anabolic stimulus and maintain insulin sensitivity, protein sufficiency to support muscle protein synthesis, sleep optimization to preserve the nocturnal testosterone pulses that drive morning levels, and metabolic health management to reduce aromatase activity driven by visceral fat